Brillante S. M., Firor R. L., Wylie P. L., Chang I. L., DiUbaldo D. Steam-phase gas chromatography analisis of flying organic admixtures in pharmaceutical preparations in obedience to Pharmacopoeia USA
2001 – Zurnal Hromatografichnogo Tovarystva – V. 1. – № 1. – P. 29-37
UDC 543.544
BRILLANTE S. M., FIROR R. L., WYLIE P. L., CHANG I. L., DIUBALDO D.
STEAM-PHASE GAS CHROMATOGRAPHY ANALISIS OF FLYING ORGANIC ADMIXTURES IN PHARMACEUTICAL PREPARATIONS IN OBEDIENCE TO PHARMACOPOEIA USA - 
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These data show the high levels of precision and linearity that can be obtained for the determination of OVIs in bulk pharmaceutical substances using the HP 7694 headspace sampler, the HP-INNOWax column, and the HP 6890 Series GC. Detection in the sub-ppm to low-ppm levels are easily achievable using the optimum conditions listed in table 1. Because the HP 7694 allows up to six samples to be heated and shaken concurrently using a preprogrammed constant heating time (CHT) along with preset sample injection intervals, samples can be continuously analyzed every 10 minutes. Up to 44 samples at a time can be loaded into the HP 7694 for continuous sampling. Inlet maintenance is minimized as is capillary column maintenance because headspace injection only introduces volatiles into the GC system.