Zrostlikova J., Binkley J., Wojtowicz P., Adam T. Application of the complete two-dimensional gas chromatography coupling with the time-of-flight mass-spectral detector in a investigation of man metabolomics

2009 – Zurnal Hromatografichnogo Tovarystva – V. IХ. – № 3, 4. –  P. 4-17

UDC 543.544.942. 543.51

ZROSTLIKOVA J., BINKLEY J., WOJTOWICZ P., ADAM T.

APPLICATION OF THE COMPLETE TWO-DIMENSIONAL GAS CHROMATOGRAPHY COUPLING WITH THE TIME-OF-FLIGHT MASS-SPECTRAL DETECTOR IN A INVESTIGATION OF MAN METABOLOMICS - article

A time-of-flight mass spectrometry in coupling with gas chromatography (GС x GС time-of-flight MS) possesses a number of the advantages, such as high selectivity of substances separation, high speed of reception and processing of data, their authenticity, good reproducibility of results, large range of determined quantities of the substances. It allows widely use of this method for the investigation of human metabolomic. Authors developed algorithm of the automated processing of markers data determination of inherited metabolic disorders (IMDs) on the base GС x GС time-of-flight MS.

Keywords: two-dimensional gas chromatography, time-of-flight mass spectrometry, metabolomic of a man, quadrupole mass analyzer markers of inherited metabolic disorders.