Articles

BARANOV YU.S., DEMCHENKO V.F., ZEMTSOVA O.V. MULTIRESIDUES METHODS OF PESTICIDES DETERMINATION IN UKRAINE

UDC 614.3:632.95:63-027.3:339.564
DOI: 10.15407/zht2018.64.005

article

BARANOV YU.S., DEMCHENKO V.F., ZEMTSOVA O.V.
Ukrainian Laboratory of Quality and Safety of agro-industrial complex products, National University of life and environmental sciences of Ukraine, Kyiv

 State Institution «Kundiiev Institute of Occupational Health of the National Academy of Medical Sciences of Ukraine», Kyiv

MULTIRESIDUES METHODS OF PESTICIDES DETERMINATION IN UKRAINE

The necessity of development of multiresidues methods (MRM) of pesticides determination in the objects of environment and foodstuffs is substantiated. An analysis of the achievements of the national school of pesticides analytical chemistry in the creation of MRM has been carried out from the analytical schemes of systematic determination of pesticide residues co-presence in one sample to multi-residue methods for measuring the mass concentration of pesticides in agro-industrial products, environmental objects using solid extraction, gas-liquid chromatography/mass spectrometry, high performance liquid chromatography/tandem mass spectrometry. The standartized harmonized MRM of pesticide determination are presented, variants of modification of QuEChERS method for testing of highly lipid matrices and determination of polar analytes, not only pesticides but also mycotoxins, polyaromatic hydrocarbons, antibiotics, polychlorinated biphenyls and other groups of xenobiotics in the objects of environment and products of agrarian-industrial complex are considered. The advantages of the modern standard method EN 15662-2008 are proved, the contribution of ukrainian analysts in improving the QuEChERS methodology is presented.
Key words: solid extraction, gas-liquid chromatography/mass spectrometry, high performance liquid chromatography/tandem mass spectrometry, multiresidues methods (MRM) of pesticides determination, QuEChERS methodology, EN 15662-2008, lipid matrices, polar analytes, mitotoxins, polyaromatic hydrocarbons, antibiotics.

REFERENCES

1.    Klisenko M.A., Aleksandrova L.A., Demchenko V.F., Makarchuk T.L. Analytical chemistry of pesticides residues: Teaching manual.  Kyiv: ECOHINTOKS, 1999, 238 p.
2.    Pysmennaya M.V., Klisenko M.A. Guidelines for determining in one sample organophosphate and organochlorine pesticides used on tomatoes by chromatographic methods (N 4994-89 by 08.06.89). Methods for the determination of trace amounts of pesticide microquantities in food, feed and the environment. Handbook. Moskow: Agropromizdat, 1992. V.2. P. 74-80.
3.    Pysmennaya M.V., Girenco D.B., Klisenko M.A. Guidelines   by determination of synthetic pyrethroids, organophosphate pesticides, sevine and benomyl with the joint presence in fruit and vegetable crops (N 4994-89 by 08.06.89). Methods for the determination of trace amounts of pesticide microquantities in food, feed and the environment. Handbook. Moskow: Agropromizdat, 1992. V.2. P. 80-83.
4.    Kofman I.Sh., Klisenko M.A., Kofanov V.I. Guidelines for the systematic gas-chromatographic determination of microquantities of herbicides of various chemical nature with the joint presence in samples of water, soil and plants (N 3022-84 by 27.04.84). Methods for the determination of trace amounts of pesticide microquantities in food, feed and the environment. Handbook. Moskow: Agropromizdat, 1992. V.2. P. 83-89.
5.    Aleksandrova L.A., Demchenko V.F., Klisenko M.A. Guidelines for the systematic analysis of biological media on the content of pesticides of various chemical nature (N 4362-87 by 08.06.87). Methods for the determination of trace amounts of pesticide microquantities in food, feed and the environment. Handbook. Moskow: Agropromizdat, 1992. V.2. P. 89-94.
6.    Girenco D.B., Klisenko M.A., Pysmennaya M.V., Chmil V.D. Unified method for the determination of pesticide residues with the joint presence in the diet (N 4380-87 by 08.06.87). Methods for the determination of trace amounts of pesticide microquantities in food, feed and the environment. Handbook. Moskow: Agropromizdat, 1992. V.2.  P. 94-97.
7.    Bublik L.I., Gavrilyuk L.L., Fedorenko N.V. Guidelines for the determination of a mixture of carbofuran with benomyl and TMTD (pesticide fotmulation COMBI) in sugar beet plants by thin layer chromatography (N 5021-89 by 08.06.89). Methods for the determination of trace amounts of pesticide microquantities in food, feed and the environment. Handbook. Moskow: Agropromizdat, 1992. V.2. P. 97-99.
8.    Kavetsky V.I., Andrienko G.G., Lesovoy V.A. Guidelines for the determination of a mixture of metaphos, bayletone and tilt in wheat plants by thin layer chromatography (N 5036-89 by 08.06.89). Methods for the determination of trace amounts of pesticide microquantities in food, feed and the environment. Handbook. Moskow: Agropromizdat, 1992. V.2. P. 100-101.
9.    Baranov Yu.S., Khilik L.A. Klisenko M.A. Guidelines for the joint determination of prometryn, terbacil and trifluralin in one sample of soil, essential oil and essential oil raw peppermint by gas-liquid chromatography (N 2363-81 by 30.03.81). Methods for the determination of trace amounts of pesticide microquantities in food, feed and the environment. Handbook. Moskow: Agropromizdat, 1992. V.2.  P. 101-105.
10.    DSTU EN 12393-1,2,3:2003. No Fatty foods Determination of pesticides residues by gas chromatography (EN 12393-1,2,3:1998, IDT).
11.    DSTU EN 1528-1-2002. Fatty products. Determination of pesticides and polychlorinated biphenyls (PCBs) (EN 1528-1:1998).
12.    DSTU ISO 10382:2004. Quality of soil. Determination of organochlorine pesticides and polychlorinated biphenyls. Gas chromatographic method with electron capture detector (ISO 10382:2002).
13.    DSTU ISO 3890-1:2007. Milk and dairy products. Determination of residues of organochlorine pesticides) (ISO 3890-1:2000).
14.    DSTU ISO 14182:2006. Animal feed. Determination of phosphorus-organic pesticide residues by gas chromatography (ISO 14182:1999, IDT).
15.    DSTU ISO 14181:2003. Animal feed. Determination of residues of chlorine-organic pesticides. Gas chromatography method (ISO 14181:2000, IDT).
16.    DSTU ISO 6468-2002 Water quality. Determination of residues of individual chloro-organic insecticides, polychlorinated biphenyls and chlorobenzenes. Method of gas chromatography after extraction (liquid-liquid).
17.    Melnichuk S.D., Lokhanska V.I., Baranov Yu.S., Tsvilihovsky V.I., Zemtsova O.V., Pavlinchuk V.I.  Method for measuring the mass fraction of residues of pesticides in the soil by gas-liquid chromatography. MVV N 081/120543-08.
18.    Melnichuk S.D., Lokhanskaya V.I., Baranov Yu.S., Tsvilihovsky V.I., Zemtsova O.V., Zhuk T.V. Determination of multiresidues of pesticides in soils of the utilized areas. Zurnal
Hromatograficnogo tovaristva, 2005. V. V, N 3. P. 4-10.
19.    Kuchma P.O., Kushnir A.G., Zemtsova O.V., Baranov Yu.S. Complex control of multiresidues of pesticides and surfactants in soils of different uses.  Zurnal Hromatograficnogo tovaristva. 2016. V.16, N 1-4. P. 31-36.
20. Lokhanska V., Melnychuk S., Baranov Yu.  Identification of  Pollutants in Soils around The Obsolete Pesticides Stocks in Ukraine Springer Science+Business Media B.V. 2008.
21. Anastassiades M., Lehotay S. J., Stajnbaher D., Schenck F. J.  Fast  and  Easy Multiresidue Method Employing Acetonitrile Extraction. Partitioning and “Dispersive Solid-Phase Extraction”  for   the  Determination of Pesticide Residues in Produce.  J. AOAC Int., 2003. N 86. P. 412-431.
22. EN 15662-2008. Foods of plant origin - Determination of pesticide residues using GC-MS and/or LC-MS/MS following acetonitrile extraction/partitioning and cleanup by dispersive SPE - QuEChERS-method.
23. Quick Method for the Analysis of Residues of numerous Highly Polar Pesticides in Food Commodities involving Simultaneous Extraction with Methanol and Determination via LC-MS/MS (QuPPe-AO-Method). CVUA Stuttgart, Schaflandstr., 3/2, 70736, Fellbach, Germany. This e-mail address is being protected from spambots. You need JavaScript enabled to view it.
24. Analysis of Acidic Pesticides using QuEChER (EN 15662) and acidified QuEChERS method. CVUA Stuttgart, Schaflandstr., 3/2, 70736, Fellbach, Germany. This e-mail address is being protected from spambots. You need JavaScript enabled to view it.
25. Sapozhnikova Y. Evaluation of low-pressure gas chromatography-tandem mass spectrometry method for the analysis of >140 pesticides in fish. J. Agric. Food Chem. 2014, N 62. P. 3684-3689.
26. Limian Zhao and Derick Lucas Multiresidues analysis of pesticides in avocados using Agilent Bond Elut EMR-Lipid by GC-MS-MS. Recommendations for use, materials. Agilent Technologies, Inc. https://www.agilent.com/cs/library/applications/
27. Limian Zhao and Derick Lucas Multiresidues analysis of veterinary drugs in the bovine liver by the method of LC-MS-MS. Recommendations for use, materials from Agilent Technologies, Inc. https://www.agilent.com/cs/library/applications/
28. Melnichuk S.D., Lohanska V. I., Baranov Yu.S., Belous A.O. Problems of determination of residues of pesticides in grain products and ways of their solution. Zurnal Hromatograficnogo tovaristva, 2009. V. IX, N 1, 2. P. 13-18.
29. Kuchma P.O., Kushnir A.G., Zemtsova O.V., Baranov Yu.S. Integrated control of multiresidues of pesticides and surfactants in soils of different uses. Zurnal Hromatograficnogo tovaristva, 2016. V.XVI, N 1. P. 31-35.