Articles

SAMCHENKO YU. M., KONOVALOVA V.V., KRYKLYA S.O., PASMURCEVA N.O., POLTORACKA T.P., SCHERBAKOV S. M., BOLDESCUL I.E., BURBAN A.F., ULBERG Z.R. SYNTHESIS AND CHAR ACTERIZATION OF MULTI-RESPONSIVE NANO-SIZED FERROGEL BASED ON N-ISOPROPYLACRYLAMIDE AND ACRYLI

2015 – Zurnal Hromatografichnogo Tovarystva – V. ХV. – № 1-4. – P. 30-40 

UDC 544.77.022.84

SAMCHENKO YU. M., KONOVALOVA V.V., KRYKLYA S.O., PASMURCEVA N.O., POLTORACKA T.P., SCHERBAKOV S. M., BOLDESCUL I.E., BURBAN A.F., ULBERG Z.R.

SYNTHESIS AND CHAR ACTERIZATION OF MULTI-RESPONSIVE NANO-SIZED FERROGEL BASED ON N-ISOPROPYLACRYLAMIDE AND ACRYLIC ACID - article

Synthesis and characterization of promising multi-responsive nano-sized hydrogel composites based on N-isopropylacrylamide, Acrylic Acid (AAc) and magnetite have been studied. Copolymer gel was used as a carrier of various drugs as well as pH and thermo-responsive component, magnetite was used as a magneto-responsive component. Composite nanoparticles were characterized by electron microscopy (TEM) and dynamic light scattering (DLS) methods. Diafiltration method was used for purification of nanogels. It was shown that the average size of nanoparticles is about 100 nm and depends on the temperature and pH of suspension. The hydrogel is characterized by clear phase transition between swollen and collapsed state upon heating above 32 °C and changing of pH value upon 4. Rapid release of incorporated drugs, used in cancer chemotherapy (photosensitizer – Methylene Blue and cytotoxic agent Doxorubicin) observed during thermo-responsive nanocomposite gels heating in the physiologically acceptable range, but still above phase transition temperature (about 40-45 °C), allows application of designed drug delivery systems in medical hyperthermia.

Keywords: thermosensitive nanogel, ferrogels, N-isopropylacrylamid, magnetite nanoparticles, dynamic light scattering, controlled drug release, Doxorubicin      

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